Molecular Profile Detail

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Profile Name FGFR2 R255W FGFR3 S249C FGFR3 V553M FGFR3 K650M
Gene Variant Detail

FGFR2 R255W (unknown)

FGFR3 K650M (gain of function)

FGFR3 S249C (gain of function)

FGFR3 V553M (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 R255W FGFR3 S249C FGFR3 V553M FGFR3 K650M transitional cell carcinoma predicted - resistant Erdafitinib Case Reports/Case Series Actionable In a clinical case study, FGFR3 V553M, FGFR3 K650M, and FGFR2 R255W, along with AKT1 E17K, was identified on post-progression biopsy in a patient with urothelial carcinoma harboring FGFR3 S249C who previously responded to Balversa (erdafitinib) (PMID: 37682528). 37682528