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| Profile Name | ROS1 rearrange ROS1 L2086F |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| ROS1 rearrange ROS1 L2086F | lung adenocarcinoma | predicted - sensitive | Cabozantinib | Case Reports/Case Series | Actionable | In a clinical case study, Cometriq (Cabometyx, cabozantinib) treatment resulted in a partial response in a heavily pretreated patient with metastatic lung adenocarcinoma harboring a ROS1 rearrangement with ROS1 L2086F (PMID: 39091594). | 39091594 |