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Ref Type Journal Article
PMID (39091594)
Authors Weber U, Davies KD, Camidge DR
Title L2086F Mutant ROS1-Rearranged NSCLC Resistant to Repotrectinib Responds to Cabozantinib: A Case Report.
Journal Vol Issue Date Pages Journal Short Title
JTO clinical and research reports 5 7 2024 Jul 100673 JTO Clin Res Rep
URL
Abstract Text Repotrectinib, licensed in November 2023, is a novel ROS1 tyrosine kinase inhibitor (TKI) with activity against G2032R, the most common resistance mutation to prior generations of ROS1 TKIs. Here, we report a case of a patient who was heavily pretreated, with advanced L1951R and L2026M mutated ROS1-rearranged NSCLC, who initially responded to repotrectinib but later developed further on-target resistance with the emergence of an L2086F mutation. The disease then responded to cabozantinib, a separate class of ROS1 TKI with preclinical activity against L2086F.

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