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Profile Name | FGFR3 S249C FGFR3 V555M |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
FGFR3 S249C FGFR3 V555M | Advanced Solid Tumor | sensitive | R3-altibody | Preclinical - Cell culture | Actionable | In a preclinical study, R3-altibody inhibited Fgfr3 downstream signaling and growth in a cell line expressing FGFR3 S249C and V555M in culture (PMID: 39082679). | 39082679 | |
FGFR3 S249C FGFR3 V555M | Advanced Solid Tumor | resistant | Erdafitinib | Preclinical - Cell culture | Actionable | In a preclinical study, a cell line expressing FGFR3 S249C and V555M was resistant to Balversa (erdafitinib) in culture (PMID: 39082679). | 39082679 | |
FGFR3 S249C FGFR3 V555M | Advanced Solid Tumor | resistant | Fexagratinib | Preclinical - Cell culture | Actionable | In a preclinical study, a cell line expressing FGFR3 S249C and V555M was resistant to AZD4547 in culture (PMID: 39082679). | 39082679 | |
FGFR3 S249C FGFR3 V555M | urinary bladder cancer | resistant | Infigratinib | Preclinical - Cell culture | Actionable | In a preclinical study, a bladder cancer cell line harboring FGFR3 S249C and expressing FGFR3 V555M was resistant to Truseltiq (infigratinib) in culture (PMID: 38437671). | 38437671 | |
FGFR3 S249C FGFR3 V555M | urinary bladder cancer | resistant | Pemigatinib | Preclinical - Cell culture | Actionable | In a preclinical study, a bladder cancer cell line harboring FGFR3 S249C and expressing FGFR3 V555M was resistant to Pemazyre (pemigatinib) in culture (PMID: 38437671). | 38437671 | |
FGFR3 S249C FGFR3 V555M | urinary bladder cancer | resistant | Erdafitinib | Preclinical - Cell culture | Actionable | In a preclinical study, a bladder cancer cell line harboring FGFR3 S249C and expressing FGFR3 V555M was resistant to Balversa (erdafitinib) in culture (PMID: 38437671). | 38437671 | |
FGFR3 S249C FGFR3 V555M | urinary bladder cancer | sensitive | KIN-3248 | Preclinical - Cell culture | Actionable | In a preclinical study, KIN-3248 inhibited viability of a bladder cancer cell line harboring FGFR3 S249C and expressing FGFR3 V555M in culture (PMID: 38437671). | 38437671 |