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| Profile Name | BARD1 Y180fs BARD1 loss |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| BARD1 Y180fs BARD1 loss | neuroblastoma | predicted - sensitive | Irinotecan + Talazoparib | Case Reports/Case Series | Actionable | In a clinical case study, treatment with the combination of Talzenna (talazoparib) and Camptosar (irinotecan) resulted in a complete response in a pediatric patient with high-risk relapsed/refractory neuroblastoma harboring germline BARD1 Y180fs and somatic Bard1 loss (PMID: 39141861). | 39141861 |