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Ref Type
PMID (39141861)
Authors Cupit-Link M, Hagiwara K, Nagy M, Koo SC, Orr BA, Ruppin E, Easton J, Zhang J, Federico SM
Title Response to PARP Inhibition in BARD1-Mutated Refractory Neuroblastoma.
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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BARD1 Y180fs BARD1 loss neuroblastoma predicted - sensitive Irinotecan + Talazoparib Case Reports/Case Series Actionable In a clinical case study, treatment with the combination of Talzenna (talazoparib) and Camptosar (irinotecan) resulted in a complete response in a pediatric patient with high-risk relapsed/refractory neuroblastoma harboring germline BARD1 Y180fs and somatic Bard1 loss (PMID: 39141861). 39141861