Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Profile Name | BRAF V600E PTEN R173C |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| BRAF V600E PTEN R173C | colorectal cancer | sensitive | Cetuximab + Encorafenib + Ribociclib | Preclinical - Patient cell culture | Actionable | In a preclinical study, the combination of Kisqali (ribociclib), Erbitux (cetuximab), and Braftovi (encorafenib) inhibited proliferation and synergistically decreased viability in a patient-derived colorectal cancer cell line harboring BRAF V600E and PTEN R173C (PMID: 39145064). | 39145064 |