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Profile Name | BRAF V600E MAP2K1 Y130C |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
BRAF V600E MAP2K1 Y130C | colorectal cancer | resistant | Cetuximab + Dabrafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Tafinlar (dabrafenib) and Erbitux (cetuximab) combination treatment inhibited senescence in a colorectal cancer cell line harboring BRAF V600E and expressing MAP2K1 Y130C in culture (PMID: 39424923). | 39424923 |