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| Profile Name | JAK2 V617F JAK2 G993A |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| JAK2 V617F JAK2 G993A | Advanced Solid Tumor | resistant | CHZ868 | Preclinical - Cell culture | Actionable | In a preclinical study, a cell line expressing JAK2 V617F and G993A was resistant to CHZ868 in culture (PMID: 37290440). | 37290440 | |
| JAK2 V617F JAK2 G993A | Advanced Solid Tumor | resistant | Ruxolitinib | Preclinical - Cell culture | Actionable | In a preclinical study, a cell line expressing JAK2 V617F and G993A was resistant to Jakafi (ruxolitinib) in culture (PMID: 37290440). | 37290440 |