Molecular Profile Detail

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Profile Name FLT3 exon 14 ins TP53 wild-type
Gene Variant Detail

FLT3 exon 14 ins (gain of function - predicted)

TP53 wild-type (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins TP53 wild-type acute myeloid leukemia sensitive Milademetan + Quizartinib Phase I Actionable In a Phase I trial, combination of Vanflyta (quizartinib) and Milademetan led to a complete response with incomplete hematologic recovery (CRi) in 40% (4/10) and stable disease (SD) in 30% of patients with TP53 wild-type acute myeloid leukemia harboring a FLT3-ITD, with a CRi of 50% (3/6) at the recommended dose; and the combination inhibited Flt3 signaling and synergistically induced apoptosis in culture and decreased leukemia growth in a cell line xenograft model (PMID: 40327322; NCT03552029). 40327322