Molecular Profile Detail

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Profile Name TP53 Y163C
Gene Variant Detail

TP53 Y163C (loss of function)

Relevant Treatment Approaches p53 Activator p53 Gene Therapy

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Y163C lung small cell carcinoma sensitive p53 Activator APR-246 + Cisplatin Preclinical Actionable In a preclinical study, the combination of APR-246 and Platinol (cisplatin) worked synergistically to inhibit growth of small lung cancer cells harboring TP53 Y163C in culture (PMID: 26086967). 26086967