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| Profile Name | KIT A502_Y503dup PTEN del exon1-2 |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| KIT A502_Y503dup PTEN del exon1-2 | gastrointestinal stromal tumor | predicted - sensitive | Everolimus + Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, treatment with the combination of Gleevec (imatinib) and Afinitor (everolimus) resulted in stable disease lasting 8.6 months in a patient with recurrent gastrointestinal stromal tumor harboring KIT A502_Y503dup (reported as Y503_F504insAY) and PTEN exon1-2 deletion, along with CDKN2A/B copy number loss (PMID: 40700673). | 40700673 |