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| Profile Name | ATM S83* |
| Gene Variant Detail | |
| Relevant Treatment Approaches | Olaparib |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| ATM S83* | Advanced Solid Tumor | sensitive | Olaparib | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with Lynparza (olaparib) inhibited survival and proliferation of cells expressing ATM S83* in a high-throughput cell culture assay (PMID: 40580951). | 40580951 |