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| Profile Name | KIT G565_P573del KIT Y823D |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| KIT G565_P573del KIT Y823D | gastrointestinal stromal tumor | predicted - resistant | Imatinib | Case Reports/Case Series | Actionable | In a clinical study, KIT Y823D was identified as a secondary mutation in a patient with gastrointestinal stromal tumor harboring a primary KIT G565_P573del mutation who developed resistance to Gleevec (imatinib) (PMID: 21475850). | 21475850 |