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| Profile Name | BRIP1 T997Rfs*61 |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| BRIP1 T997Rfs*61 | pancreatic adenocarcinoma | predicted - sensitive | Olaparib | Case Reports/Case Series | Actionable | In a Phase II trial, treatment with Lynparza (olaparib) resulted in a clinical benefit rate of 62.5% in advanced solid tumor patients harboring BRIP1 mutations, including a partial response in a patient with pancreatic adenocarcinoma harboring BRIP1 T997Rfs*61 (reported as c.2990_2993del) (PMID: 42105598). | 42105598 |