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| Profile Name | PALB2 L1142Yfs*21 |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| PALB2 L1142Yfs*21 | breast carcinoma | predicted - sensitive | Olaparib | Case Reports/Case Series | Actionable | In a Phase II trial, treatment with Lynparza (olaparib) resulted in an objective response rate of 25.0% (2/8) and clinical benefit rate of 50.0% in advanced solid tumor patients harboring PALB2 mutations, including a partial response in a patient with breast carcinoma harboring PALB2 L1142Yfs*21 (reported as c.3424del) (PMID: 42105598). | 42105598 |