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| Profile Name | HRAS G12C HRAS T58I |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| HRAS G12C HRAS T58I | rhabdomyosarcoma | resistant | Sotorasib | Preclinical - Cell culture | Actionable | In a preclinical study, a rhabdomyosarcoma cell line harboring HRAS G12C and HRAS T58I was resistant to Lumakras (sotorasib) in culture (PMID: 41340466). | 41340466 | |
| HRAS G12C HRAS T58I | rhabdomyosarcoma | resistant | RMC-6291 | Preclinical - Cell culture | Actionable | In a preclinical study, a rhabdomyosarcoma cell line harboring HRAS G12C and HRAS T58I was resistant to RMC-6291 treatment in culture (PMID: 41340466). | 41340466 |