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| Profile Name | HRAS A146P |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| HRAS A146P | head and neck squamous cell carcinoma | sensitive | Darlifarnib | Preclinical - Pdx | Actionable | In a preclinical study, Darlifarnib (KO-2806) inhibited tumor growth in a patient-derived xenograft (PDX) model of head and neck squamous cell carcinoma harboring HRAS A146P (PMID: 41661652). | 41661652 |