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| Profile Name | RAD51C D141H |
| Gene Variant Detail | |
| Relevant Treatment Approaches | Olaparib |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| RAD51C D141H | Advanced Solid Tumor | no benefit | Saruparib | Preclinical - Cell culture | Actionable | In a preclinical study, Saruparib (AZD5305) treatment did not inhibit colony formation in cells expressing RAD51C D141H in culture (PMID: 42625895). | 42625895 | |
| RAD51C D141H | Advanced Solid Tumor | no benefit | Ceralasertib | Preclinical - Cell culture | Actionable | In a preclinical study, Ceralasertib (AZD6738) treatment did not inhibit colony formation in cells expressing RAD51C D141H in culture (PMID: 42625895). | 42625895 | |
| RAD51C D141H | Advanced Solid Tumor | sensitive | Ceralasertib + Saruparib | Preclinical - Cell culture | Actionable | In a preclinical study, Ceralasertib (AZD6738) and Saruparib (AZD5305) synergistically inhibited colony formation in cell lines expressing RAD51C D141H in culture (PMID: 42625895). | 42625895 |