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| Profile Name | JAK2 R683G |
| Gene Variant Detail | |
| Relevant Treatment Approaches | JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| JAK2 R683G | Advanced Solid Tumor | sensitive | JAK2 Inhibitor | CHZ868 | Preclinical - Cell culture | Actionable | In a preclinical study, CHZ868 inhibited viability of a cell line expressing JAK2 R683G in culture (PMID: 37290440). | 37290440 |