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Molecular Profile HRAS mutant
Therapy Cabozantinib
Indication/Tumor Type medullary thyroid carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS mutant medullary thyroid carcinoma sensitive Cabozantinib Guideline Actionable Cometriq (cabozantinib) is included in guidelines for patients with advanced or metastatic medullary thyroid carcinoma harboring RAS mutations (PMID: 31549998, PMID: 35491008; ESMO.org). 35491008 31549998 detail...
HRAS mutant medullary thyroid carcinoma sensitive Cabozantinib Phase III Actionable In a Phase III trial, Cometriq (cabozantinib) treatment resulted in improved progression-free survival (47 vs 8 weeks, HR 0.15, p=0.0317) compared to placebo in thyroid medullary carcinoma patients harboring RAS mutations (PMID: 27525386). 27525386
PubMed Id Reference Title Details
(27525386) Correlative analyses of RET and RAS mutations in a phase 3 trial of cabozantinib in patients with progressive, metastatic medullary thyroid cancer. Full reference...
ESMO Clinical Practice Guidelines Full reference...
(35491008) ESMO Clinical Practice Guideline update on the use of systemic therapy in advanced thyroid cancer. Full reference...
(31549998) Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Full reference...