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Molecular Profile | FLT3 D835Y |
Therapy | Arsenic trioxide + Cytarabine + Methotrexate + Tretinoin |
Indication/Tumor Type | acute promyelocytic leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 D835Y | acute promyelocytic leukemia | predicted - sensitive | Arsenic trioxide + Cytarabine + Methotrexate + Tretinoin | Case Reports/Case Series | Actionable | In a clinical case study, a patient with acute promyelocytic leukemia harboring FLT3 D835Y demonstrated a complete molecular remission after treatment with Trisenox (arsenic trioxide) and Vesanoid (tretinoin) combined with Cytosar-U (cytarabine) and Methotrexate (PMID: 27626069). | 27626069 |
PubMed Id | Reference Title | Details |
---|---|---|
(27626069) | Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia. | Full reference... |