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Molecular Profile | KIT D816Y |
Therapy | Avapritinib |
Indication/Tumor Type | mast cell neoplasm |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT D816Y | mast cell neoplasm | predicted - sensitive | Avapritinib | Preclinical | Actionable | In a preclinical study, Ayvakit (avapritinib) inhibited Kit phosphorylation and proliferation of murine mastocytoma cells harboring KIT D814Y (corresponding to human D816Y) in culture, and resulted in tumor regression in allograft animal models (PMID: 29093181). | 29093181 |
PubMed Id | Reference Title | Details |
---|---|---|
(29093181) | A precision therapy against cancers driven by KIT/PDGFRA mutations. | Full reference... |