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Molecular Profile | KIT D820V |
Therapy | Avapritinib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT D820V | gastrointestinal stromal tumor | predicted - sensitive | Avapritinib | Case Reports/Case Series | Actionable | In a Phase I trial, Ayvakit (avapritinib) treatment resulted in tumor reduction lasting through 15 cycles of treatment in a patient with gastrointestinal stromal tumor harboring KIT D820V, whose disease had progressed on previous Gleevec (imatinib), Sutent (sunitinib), and Stivarga (regorafenib) treatment (PMID: 29093181; NCT02508532). | 29093181 |
PubMed Id | Reference Title | Details |
---|---|---|
(29093181) | A precision therapy against cancers driven by KIT/PDGFRA mutations. | Full reference... |