Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Relevant Treatment Approaches	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT D820V	gastrointestinal stromal tumor	predicted - sensitive	KIT Inhibitor	Avapritinib	Case Reports/Case Series	Actionable	In a Phase I trial, Ayvakit (avapritinib) treatment resulted in tumor reduction lasting through 15 cycles of treatment in a patient with gastrointestinal stromal tumor harboring KIT D820V, whose disease had progressed on previous Gleevec (imatinib), Sutent (sunitinib), and Stivarga (regorafenib) treatment (PMID: 29093181; NCT02508532).	29093181
KIT D820V	mucosal melanoma	predicted - sensitive	KIT Inhibitor	Nilotinib	Case Reports/Case Series	Actionable	In a Phase II trial (NICAM), Tasigna (nilotinib) treatment demonstrated activity in patients with acral (n=6) or mucosal melanoma (n=20) harboring KIT mutations, resulting in an objective response rate at 12 weeks of 19% (5/26), including a mucosal melanoma patient harboring KIT D820V, who had a 38.1% reduction of target lesions, remained on treatment for 54.2 months, with a progression-free survival of 15.6 months, and overall survival of 63.7 months (PMID: 38417447).	38417447

Profile Name	KIT D820V
Gene Variant Detail	KIT D820V (unknown)
Relevant Treatment Approaches	KIT Inhibitor