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Molecular Profile | CTNNB1 S45del |
Therapy | NTRC 0066-0 |
Indication/Tumor Type | colon carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CTNNB1 S45del | colon carcinoma | predicted - sensitive | NTRC 0066-0 | Preclinical - Cell culture | Actionable | In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to NTRC 0066-0 compared to cell lines with wild-type CTNNB1 or an isogenic cell line lacking the CTNNB1 mutation, in culture (PMID: 28751540). | 28751540 |
PubMed Id | Reference Title | Details |
---|---|---|
(28751540) | TTK Inhibitors as a Targeted Therapy for CTNNB1 (β-catenin) Mutant Cancers. | Full reference... |