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Molecular Profile | BRAF L514V BRAF V600E |
Therapy | Dabrafenib |
Indication/Tumor Type | ganglioglioma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF L514V BRAF V600E | ganglioglioma | resistant | Dabrafenib | Case Reports/Case Series | Actionable | In a clinical case study, a pediatric patient with anaplastic ganglioglioma harboring BRAF V600E progressed after initial response to Tafinlar (dabrafenib) treatment, and was found to have acquired a BRAF L514V in cis with BRAF V600E, which conferred dabrafenib resistance in culture (PMID: 29880583). | 29880583 |
PubMed Id | Reference Title | Details |
---|---|---|
(29880583) | A Secondary Mutation in BRAF Confers Resistance to RAF Inhibition in a BRAFV600E-Mutant Brain Tumor. | Full reference... |