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ID | DOID:5078 |
Name | ganglioglioma |
Definition | A cell type benign neoplasm that has_material_basis_in glial-type cells. |
Source | DiseaseOntology.org |
Alt Ids | DOID:5607 DOID:5606 |
Path | disease disease of cellular proliferation benign neoplasm cell type benign neoplasm ganglioglioma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
BRAF V600E | Dabrafenib | ganglioglioma | predicted - sensitive | detail... |
BRAF L514V BRAF V600E | Dabrafenib | ganglioglioma | resistant | detail... |
BRAF V600X | Dabrafenib | ganglioglioma | predicted - sensitive | detail... |
BRAF V600E | Dabrafenib + Trametinib | ganglioglioma | sensitive | detail... |
BRAF V600E | Cobimetinib + Vemurafenib | ganglioglioma | sensitive | detail... |
BRAF V600E | Vemurafenib | ganglioglioma | predicted - sensitive | detail... |
BRAF T599dup | Dabrafenib + Trametinib | ganglioglioma | predicted - sensitive | detail... |
BRAF V600D | Dabrafenib + Trametinib | ganglioglioma | predicted - sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT01999270 | Phase I | Bevacizumab + Irinotecan | Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors | Completed | USA | 0 |
NCT03919071 | Phase II | Dabrafenib + Trametinib | Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma | Recruiting | USA | 1 |
NCT03975829 | FDA approved | Dabrafenib + Trametinib | Pediatric Long-Term Follow-up and Rollover Study | Active, not recruiting | USA | SWE | NLD | ITA | ISR | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUS | ARG | 2 |
NCT04923126 | Phase Ib/II | PD-0325901 | SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma | Recruiting | USA | 0 |
NCT05503797 | Phase II | Cobicistat + PLX8394 PLX8394 | A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations | Recruiting | USA | SWE | ITA | GBR | FRA | ESP | DEU | CAN | 1 |