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| Molecular Profile | CD274 positive |
| Therapy | CDX-527 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 positive | Advanced Solid Tumor | predicted - sensitive | CDX-527 | Preclinical - Cell culture | Actionable | In a preclinical study, CDX-527 inhibited PD-1 signaling, and stimulated T cell response in culture (AACR Annual Meeting 2019, Abstract 2392). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| CDX-527: A novel bispecific immune-modulating antibody targeting CD27 and PD-L1 | Full reference... |