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Molecular Profile | CD274 positive |
Therapy | CDX-527 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CD274 positive | Advanced Solid Tumor | predicted - sensitive | CDX-527 | Preclinical - Cell culture | Actionable | In a preclinical study, CDX-527 inhibited PD-1 signaling, and stimulated T cell response in culture (AACR Annual Meeting 2019, Abstract 2392). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
CDX-527: A novel bispecific immune-modulating antibody targeting CD27 and PD-L1 | Full reference... |