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Ref Type
PMID
Authors Laura A. Vitale, Lawrence J. Thomas, Thomas O'Neill, Jenifer Widger, Laura Mills-Chen, Andrea Crocker, Colleen Patterson, Anna Wasiuk, Eric Forsberg, James Boyer, Crystal Sisson, Jeffrey Weidlick
Title CDX-527: A novel bispecific immune-modulating antibody targeting CD27 and PD-L1
URL https://www.abstractsonline.com/pp8/#!/6812/presentation/2483
Abstract Text AACR Annual Meeting 2019, Abstract 2392

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
CDX-527 CDX-527 1 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
CDX-527 CDX527|CDX 527 CD27 Antibody 3 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 CDX-527 is a tetravalent human antibody targeting both CD27 and PD-L1 (CD274), which may lead to enhanced immune activation (AACR Annual Meeting 2019, Abstract 2392, PMID: 32451681).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive Advanced Solid Tumor predicted - sensitive CDX-527 Preclinical - Cell culture Actionable In a preclinical study, CDX-527 inhibited PD-1 signaling, and stimulated T cell response in culture (AACR Annual Meeting 2019, Abstract 2392). detail...