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Therapy Name CDX-527
Synonyms
Therapy Description

CDX-527 is a tetravalent human antibody targeting both CD27 and PD-L1 (CD274), which may lead to enhanced immune activation (AACR Annual Meeting 2019, Abstract 2392, PMID: 32451681).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CDX-527 CDX527|CDX 527 CD27 Antibody 3 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 CDX-527 is a tetravalent human antibody targeting both CD27 and PD-L1 (CD274), which may lead to enhanced immune activation (AACR Annual Meeting 2019, Abstract 2392, PMID: 32451681).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive Advanced Solid Tumor predicted - sensitive CDX-527 Preclinical - Cell culture Actionable In a preclinical study, CDX-527 inhibited PD-1 signaling, and stimulated T cell response in culture (AACR Annual Meeting 2019, Abstract 2392). detail...

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04440943 Phase I CDX-527 A Study of the PD-L1xCD27 Bispecific Antibody CDX-527 in Patients With Advanced Malignancies Completed USA 0


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