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Molecular Profile | TP53 mutant |
Therapy | JQ1 |
Indication/Tumor Type | medulloblastoma |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 mutant | medulloblastoma | decreased response | JQ1 | Preclinical | Actionable | In a preclinical study, medulloblastoma cell lines with TP53 mutations had significantly less sensitivity to the BET inhibitor, JQ1, than cell lines carrying wild-type TP53 (PMID: 24231268). | 24231268 |
PubMed Id | Reference Title | Details |
---|---|---|
(24231268) | BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. | Full reference... |