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Molecular Profile | BRAF V600E PTEN loss |
Therapy | Everolimus |
Indication/Tumor Type | melanoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E PTEN loss | melanoma | predicted - resistant | Everolimus | Case Reports/Case Series | Actionable | In a retrospective analysis, a melanoma patient harboring PTEN loss and BRAF V600E demonstrated resistance to Afinitor (everolimus) treatment, resulting in progressive disease (PMID: 20664172). | 20664172 |
PubMed Id | Reference Title | Details |
---|---|---|
(20664172) | Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. | Full reference... |