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Molecular Profile | KIT exon 11 del |
Therapy | Adavosertib + Avapritinib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT exon 11 del | gastrointestinal stromal tumor | sensitive | Adavosertib + Avapritinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Adavosertib (MK-1775) and Ayvakit (avapritinib) demonstrated an additive effect on inhibiting cell growth and inducing apoptosis in gastrointestinal stromal tumor cells harboring a KIT exon 11 deletion in culture, and inhibited tumor growth and led to prolonged survival in cell line xenograft models (PMID: 33320833). | 33320833 |
PubMed Id | Reference Title | Details |
---|---|---|
(33320833) | Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment. | Full reference... |