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Molecular Profile KIT exon 11 del
Therapy Adavosertib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT exon 11 del gastrointestinal stromal tumor no benefit Adavosertib Preclinical - Cell line xenograft Actionable In a preclinical study, Adavosertib (MK-1775) treatment resulted in reduced cell viability of gastrointestinal stromal tumor cells harboring a KIT exon 11 deletion in culture, but did not lead to improved tumor growth inhibition or prolonged survival compared to controls in cell line xenograft models (PMID: 33320833). 33320833
PubMed Id Reference Title Details
(33320833) Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment. Full reference...