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Molecular Profile | CD274 over exp STK11 mut |
Therapy | unspecified immune checkpoint inhibitor |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | not predictive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CD274 over exp STK11 mut | lung adenocarcinoma | not predictive | unspecified immune checkpoint inhibitor | Clinical Study - Cohort | Actionable | In a clinical study, lung adenocarcinoma patients with high expression of CD274 (PD-L1; >/= 50%) and a co-occurring STK11 mutation demonstrated a similar objective response rate (P=0.2), progression-free survival (P=0.29), and overall survival (0.44) compared to patients with negative expression of CD274 (PD-L1) and a co-occurring EGFR mutation when treated with an unspecified immune checkpoint inhibitor (PMID: 32178965). | 32178965 |
PubMed Id | Reference Title | Details |
---|---|---|
(32178965) | Clinical and molecular correlates of PD-L1 expression in patients with lung adenocarcinomas. | Full reference... |