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Molecular Profile CD274 positive
Therapy Nivolumab
Indication/Tumor Type stomach cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive stomach cancer sensitive Nivolumab Guideline Actionable Opdivo (nivolumab) in combination with platinum and fluoropyrimidine-based chemotherapy is included in the Pan-Asian Guidelines Adaptation (PAGA) as first-line therapy for patients with advanced untreated gastric cancer with a CD274 (PD-L1) expression of CPS >/=5 (PMID: 38458658; ESMO.org). 38458658 detail...
CD274 positive stomach cancer sensitive Nivolumab Guideline Actionable Opdivo (nivolumab) in combination with fluoropyrimidine and platinum-based chemotherapy is included in guidelines as first-line therapy for patients with advanced, untreated gastric cancer expressing PD-L1 (CD274, CPS>=5) (PMID: 35914639; ESMO.org). detail... 35914639
CD274 positive stomach cancer sensitive Nivolumab Guideline Actionable Opdivo (nivolumab), in combination with first-line chemotherapy including fluoropyrimidine and oxaliplatin, is included in guidelines as preferred first-line therapy for patients with gastric cancer expressing PD-L1 (CD274, CPS>=5), and without ERBB2 (HER2) overexpression (category 1), and as first-line therapy for patients with PD-L1 expression (CD274, CPS <5) and without ERBB2 (HER2) overexpression (category 2B) (NCCN.org). detail...
PubMed Id Reference Title Details
NCCN.org Full reference...
ESMO Clinical Practice Guidelines Full reference...
ESMO Clinical Practice Guidelines Full reference...
(35914639) Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Full reference...
(38458658) Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with gastric cancer. Full reference...