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Molecular Profile | VHL inact mut |
Therapy | Belzutifan |
Indication/Tumor Type | renal cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
VHL inact mut | renal cell carcinoma | sensitive | Belzutifan | Guideline | Actionable | Welireg (belzutifan) is included in guidelines for patients with Von Hippel-Lindau disease-associated renal cell carcinoma that do not require immediate surgery (NCCN.org). | detail... |
VHL inact mut | renal cell carcinoma | sensitive | Belzutifan | Guideline | Actionable | Welireg (belzutifan) is included in guidelines for patients with localized Von Hippel-Lindau disease-associated renal cell carcinoma harboring germline VHL mutations (PMID: 38788900; ESMO.org). | detail... 38788900 |
VHL inact mut | renal cell carcinoma | sensitive | Belzutifan | FDA approved | Actionable | In a Phase II trial that supported FDA approval, Welireg (belzutifan) treatment was safe and resulted in an objective response in 49% (30/61, 30 partial responses) and stable disease in 49% of patients with Von Hippel-Lindau disease-associated localized renal cell carcinoma harboring germline VHL mutations, 94% of patients were progression-free at 24 months and median duration of response was not reached with a median follow-up of 21.8 months (PMID: 34818478; NCT03401788). | 34818478 detail... |
PubMed Id | Reference Title | Details |
---|---|---|
NCCN.org | Full reference... | |
ESMO Clinical Practice Guidelines | Full reference... | |
Welireg (belzutifan) FDA Drug Label | Full reference... | |
(38788900) | Renal cell carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. | Full reference... |
(34818478) | Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease. | Full reference... |