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| Molecular Profile | IDH1 R132H |
| Therapy | AGI-5198 |
| Indication/Tumor Type | high grade glioma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132H | high grade glioma | sensitive | AGI-5198 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AGI-5198 inhibited growth of a glioma cell line harboring IDH1 R132H in culture and in xenograft models (PMID: 23558169). | 23558169 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23558169) | An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. | Full reference... |