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Molecular Profile | EML4 - ALK ALK L1196M |
Therapy | Ensartinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK L1196M | Advanced Solid Tumor | sensitive | Ensartinib | Preclinical | Actionable | In a preclinical study, Ensacove (ensartinib) inhibited growth and Alk phosphorylation in cells expressing the Xalkori (crizotinib) resistance mutation, EML4-ALK ALK L1196M (PMID: 21613408). | 21613408 |
PubMed Id | Reference Title | Details |
---|---|---|
(21613408) | Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. | Full reference... |