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| Molecular Profile | RET M918T |
| Therapy | LOX-18228 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET M918T | Advanced Solid Tumor | predicted - sensitive | LOX-18228 | Preclinical - Cell culture | Actionable | In a preclinical study, LOX-18228 treatment resulted in reduced viability in a cell line expressing RET M918T in culture (Cancer Res 2021;81(13_Suppl):Abstract nr 1464). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Abstract 1464: Pre-clinical characterization of potent and selective next-generation RET inhibitors | Full reference... |