Therapy Detail
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| Therapy Name | LOX-18228 |
| Synonyms | |
| Therapy Description |
LOX-18228 is a next-generation RET inhibitor, potentially resulting in decreased cell growth, inhibition of tumor growth, and tumor regression (Cancer Res 2021;81(13_Suppl):Abstract nr 1464). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| LOX-18228 | LOX 18228|LOX18228 | RET Inhibitor 53 | LOX-18228 is a next-generation RET inhibitor, potentially resulting in decreased cell growth, inhibition of tumor growth, and tumor regression (Cancer Res 2021;81(13_Suppl):Abstract nr 1464). |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET M918T | Advanced Solid Tumor | predicted - sensitive | LOX-18228 | Preclinical - Cell culture | Actionable | In a preclinical study, LOX-18228 treatment resulted in reduced viability in a cell line expressing RET M918T in culture (Cancer Res 2021;81(13_Suppl):Abstract nr 1464). | detail... |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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