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Therapy Name LOX-18228
Synonyms
Therapy Description

LOX-18228 is a next-generation RET inhibitor, potentially resulting in decreased cell growth, inhibition of tumor growth, and tumor regression (Cancer Res 2021;81(13_Suppl):Abstract nr 1464).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
LOX-18228 LOX 18228|LOX18228 RET Inhibitor 53 LOX-18228 is a next-generation RET inhibitor, potentially resulting in decreased cell growth, inhibition of tumor growth, and tumor regression (Cancer Res 2021;81(13_Suppl):Abstract nr 1464).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET M918T Advanced Solid Tumor predicted - sensitive LOX-18228 Preclinical - Cell culture Actionable In a preclinical study, LOX-18228 treatment resulted in reduced viability in a cell line expressing RET M918T in culture (Cancer Res 2021;81(13_Suppl):Abstract nr 1464). detail...

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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