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Molecular Profile | RB1 inact mut |
Therapy | Nutlin-3a |
Indication/Tumor Type | retinoblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RB1 inact mut | retinoblastoma | sensitive | Nutlin-3a | Preclinical | Actionable | In a preclinical study, Nutlin-3a induced p53 pathway signaling in MDMX mouse models with retinoblastoma and 69% (70/102) of the eyes harvested from the mouse models demonstrated complete response or stable disease after 18 weeks of therapy (PMID: 21515735). | 21515735 |
PubMed Id | Reference Title | Details |
---|---|---|
(21515735) | Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. | Full reference... |