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Molecular Profile | NRAS K135N |
Therapy | Cetuximab |
Indication/Tumor Type | colorectal cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS K135N | colorectal cancer | predicted - sensitive | Cetuximab | Preclinical - Cell line xenograft | Actionable | In a preclinical study, a cell line xenograft model of colorectal cancer expressing NRAS K135N demonstrated similar sensitivity to Erbitux (cetuximab) treatment compared to a NRAS wild-type model (PMID: 34117033). | 34117033 |
PubMed Id | Reference Title | Details |
---|---|---|
(34117033) | Clinical and Functional Characterization of Atypical KRAS / NRAS Mutations in Metastatic Colorectal Cancer. | Full reference... |