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| Molecular Profile | TSC2 R611W |
| Therapy | Everolimus |
| Indication/Tumor Type | giant cell glioblastoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TSC2 R611W | giant cell glioblastoma | predicted - sensitive | Everolimus | Case Reports/Case Series | Actionable | In a clinical case study, Afinitor (everolimus) treatment with adjuvant electromagnetic field therapy resulted in complete remission ongoing 33 months after diagnosis in a patient with gigantocellular glioblastoma harboring TSC2 R611W who was previously treated with surgical resection and radiotherapy (PMID: 31154346). | 31154346 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31154346) | Successful treatment of a TSC2-mutant glioblastoma with everolimus. | Full reference... |