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| Molecular Profile | KIT V560E |
| Therapy | Imatinib |
| Indication/Tumor Type | gastrointestinal stromal tumor |
| Response Type | conflicting |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V560E | gastrointestinal stromal tumor | conflicting | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, neoadjuvant Gleevec (imatinib) treatment resulted in decreased tumor size with a maximal response at 12 months in a patient with gastrointestinal stromal tumor (GIST) harboring KIT V560E, allowing for surgical resection (PMID: 34250403). | 34250403 |
| KIT V560E | gastrointestinal stromal tumor | conflicting | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with gastrointestinal stromal tumor harboring KIT V560E was resistant to Gleevec (imatinib) treatment, and in a preclinical study, a patient-derived organoid model was resistant to Gleevec (imatinib) treatment in culture (PMID: 35982969). | 35982969 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34250403) | Synchronous, Yet Genomically Distinct, GIST Offer New Insights Into Precise Targeting of Tumor Driver Mutations. | Full reference... |
| (35982969) | Patient-Derived Organoid Facilitating Personalized Medicine in Gastrointestinal Stromal Tumor With Liver Metastasis: A Case Report. | Full reference... |