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| Molecular Profile | RAD51C del |
| Therapy | Saruparib |
| Indication/Tumor Type | ovarian cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RAD51C del | ovarian cancer | sensitive | Saruparib | Preclinical - Cell culture | Actionable | In a preclinical study, Saruparib (AZD5305) inhibited colony formation in an ovarian cancer cell line with RAD51C deletion in culture (PMID: 35929986). | 35929986 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (35929986) | Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper. | Full reference... |