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Molecular Profile BRAF G466A
Therapy Dabrafenib + Trametinib
Indication/Tumor Type collecting duct carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G466A collecting duct carcinoma predicted - sensitive Dabrafenib + Trametinib Case Reports/Case Series Actionable In a clinical case study, Tafinlar (dabrafenib) and Mekinist (trametinib) combination treatment resulted in decreased FDG avidity in the metastases in a patient with metastatic Bellini duct carcinoma harboring BRAF G466A, whose disease remained stable for 11 months (PMID: 33669326). 33669326
PubMed Id Reference Title Details
(33669326) Tumor Type Agnostic Therapy Carrying BRAF Mutation: Case Reports and Review of Literature. Full reference...