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Molecular Profile | BRAF G466A |
Therapy | Dabrafenib + Trametinib |
Indication/Tumor Type | collecting duct carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF G466A | collecting duct carcinoma | predicted - sensitive | Dabrafenib + Trametinib | Case Reports/Case Series | Actionable | In a clinical case study, Tafinlar (dabrafenib) and Mekinist (trametinib) combination treatment resulted in decreased FDG avidity in the metastases in a patient with metastatic Bellini duct carcinoma harboring BRAF G466A, whose disease remained stable for 11 months (PMID: 33669326). | 33669326 |
PubMed Id | Reference Title | Details |
---|---|---|
(33669326) | Tumor Type Agnostic Therapy Carrying BRAF Mutation: Case Reports and Review of Literature. | Full reference... |