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| Molecular Profile | VHL Y112C |
| Therapy | ARV-771 |
| Indication/Tumor Type | colon carcinoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| VHL Y112C | colon carcinoma | resistant | ARV-771 | Preclinical - Cell culture | Actionable | In a preclinical study, a colon carcinoma cell line expressing VHL Y112C was resistant to ARV-771 in culture (PMID: 36329119). | 36329119 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36329119) | Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. | Full reference... |