Profile Response Detail

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Molecular Profile BRAF V600E
Therapy Dabrafenib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E gastrointestinal stromal tumor predicted - sensitive Dabrafenib Case Reports/Case Series Actionable In a clinical case study, third-line treatment with Tafinlar (dabrafenib) resulted in a partial response lasting 19 months in a patient with gastrointestinal stromal tumor harboring BRAF V600E (PMID: 38756640). 38756640
BRAF V600E gastrointestinal stromal tumor predicted - sensitive Dabrafenib Case Reports/Case Series Actionable In a clinical case study, Tafinlar (dabrafenib) treatment resulted in a 20% decrease in tumor size after 24 weeks in a patient with a gastrointestinal stromal tumor harboring BRAF V600E (PMID: 23470635). 23470635
PubMed Id Reference Title Details
(23470635) BRAF mutant gastrointestinal stromal tumor: first report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance. Full reference...
(38756640) Treatment of BRAF V600E mutant gastrointestinal stromal tumor with dabrafenib: a case report. Full reference...